Dissecting early pathogenesis of BRCA1/2-associated cancer for risk prediction and prevention

Principal Investigator: Leif Ellison | Affiliation: Massachusett's General Hospital

Research Keywords

Precancer biology, immunology

Research Questions

• What are the early changes in cells of BRCA carrier breast tissue?
• What are the BRCA cellular vulnerabilities?
• What are tissue-based markers for prevention approaches?

Specific Aims

• Aim 1:
• Aim 2:
• Aim 3:

Methods

1. Singe cell RNA sequencing
2. Organoid cultures